The > 30 million persons in the EU and nearly 11 million in US with osteoporosis experience about 3.9 million and 2.3 million fractures/year and have annual hospital costs exceeding €50 billion and $28 billion.
Net cost benefit was calculated by subtracting the supplements’ market costs from those savings. Analyses estimated the total number of avoided fractures and associated cost savings with supplement use. Other model inputs were informed by epidemiologic, clinical, and cost data (2016–2017) obtained via the medical literature or public databases. A 14% relative risk reduction of fracture with calcium/vitamin D supplementation from a recent systematic review and meta-analysis of randomized, controlled trials was used as the basis for the benefit estimate. MethodsĪ cost-benefit analysis tool was used to estimate the net cost savings from reduced fracture-related hospital expenses if adults with osteoporosis in the EU and US used calcium/vitamin D supplements. PurposeĮvaluate the cost-effectiveness of calcium/vitamin D supplementation for preventing osteoporotic fractures. If all adults with osteoporosis in the European Union (EU) and United States (US) used calcium and vitamin D supplements, it could prevent more than 500,000 fractures/year in the EU and more than 300,000/year in the US and save approximately €5.7 billion and US $3.3 billion annually.
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